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Warfarin's a lot less strong R-enantiomer is metabolized in part by CYP3A4 (in addition to CYP1A2 and CYP2C19). Keep an eye on INR a lot more routinely if coadministered with inhibitors of these isoenzymes and alter warfarin dose if needed.modafinil will raise the degree or influence of pantoprazole by impacting hepatic enzyme CYP2C19 metabolism. I